Control of Autonomous Underwater Vehicles

In this thesis an overview of Autonomous Underwater Vehicles (AUV) is presented which covers the advancements in AUV technology in last two decades, different components of AUV and the applications of AUVs. A glimpse on AUV research in India is presented. A nonlinear model of AUV is obtained through kinematics and dynamics equation which is linearized about an operating point to get linearized pitch & depth plane model. A two loop controller (PI control) is used to control the pitch and in turn the depth of the AUV. After having developed, simulated and analyzed the pitch and depth controller for a single AUV, we focus our attention towards developing formation control of three AUVs. The formation control for multiple Autonomous Underwater Vehicles (AUVs) is considered in spatial motions.The objective is to drive a leader AUV along a desired trajectory, and make the follower AUVs keep a desired formation with respect to the leader’s configuration in 3-dimensional spaces (leader-follower formation control). Also, an obstacle avoidance scheme, using pitch and depth control, is used to avoid static obstacles in the path of AUV. The results of the above three control objectives such as tracking control of AUV, controller for avoiding obstacles and formation control of multiple AUVs are presented and discussed in the thesis

Role of Access Control in Information Security: A Security Analysis Approach

Information plays a vital role in decision-making and driving the world further in the ever-growing digital world. Authorization, which comes immediately after authentication, is essential in restricting access to information in the digital world. Various access control models have been proposed to ensure authorization by specifying access control policies. Security analysis of access control policies is a highly challenging task. Additionally, the security analysis of decentralized access control policies is complex because decentralization simplifies policy administration but raises security concerns. Therefore, an efficient security analysis approach is required to ensure the correctness of access control policies. This chapter presents a propositional rule-based machine learning approach for analyzing the Role-Based Access Control (RBAC) policies. Specifically, the proposed method maps RBAC policies into propositional rules to analyze security policies. Extensive experiments on various datasets containing RBAC policies demonstrate that the machine learning-based approach can offer valuable insight into analyzing RBAC policies

National Securities Laws and Global Effect of National Security: An Analytical Study

Nations all around the world grapple with the issue of security, specifically how to define what constitutes national security, enact appropriate legislation, ensure applications, and provide security. It is imperative to remember that governments have duties to protect those who live within its boundaries as well as those who are residents of their country.In this fast changing environment, security threats can come from a variety of unanticipated sources. Non-state actors, groups, loose networks, and even disconnected persons may now pose serious challenges to national security, in contrast to prior threats from other governments or nations that anticipated new threats. In this research article the researcher explain how to safe national security  and how to stop the terrorism in India

National Security Laws in India and terrorism in Present Scenario: A Socio-Legal Study

A sovereign state's inhabitants, economy, and institutions are all subject to national obligations, which are known as national security or national defense. National security, which was initially intended to defend against military attacks, now encompasses non-military elements including security from terrorism, crime prevention, economic security, energy security, environmental security, food security, and cybersecurity. Are also frequently mentioned. Similar to how other governments can act, violent non-state actors, drug cartels, multinational businesses, and natural disasters can all pose a threat to national security. To maintain national security, governments use a variety of political, economic, military, and diplomatic tools. They can also act to create regional and international conditions of security by reducing transnational sources of insecurity such as climate change, economic inequality, political exclusion, and nuclear proliferation. In this research article, I will discuss related to terrorism's impact on society, how to stop terrorism, and various ways of National security

Nitric oxide-mediated augmentation of polymorphonuclear free radical generation after hypoxia-reoxygenation

Polymorphonuclear leukocytes (PMNLs), nitric oxide (NO), calcium, and free radicals play an important role in hypoxia/ischemia and reoxygenation injury. In the present study, NO donors, sodium nitroprusside (SNP), and diethylamine-NO (DEA-NO) at low concentrations (10 and 100 nmol/L) potentiated, while higher (10 μ mol/L to 10 mmol/L) concentrations inhibited free radical generation response in the rat PMNLs. Free radical generation response was found to be significantly augmented when hypoxic PMNLs were reoxygenated (hypoxia-reoxygenation [H-R]). This increase in free radical generation after reoxygenation or SNP (10 nmol/L) was blocked in the absence of extracellular calcium. SNP (10 nmol/L) or H-R-mediated increases in the free radical generation were prevented by the pretreatment of PMNLs with NO scavenger (hemoglobin), the polyadenine diphosphate (ADP)-ribosylation synthase inhibitor (benzamide) or the calcium channel antagonist (felodipine). A significant augmentation in the nitrite and intracellular calcium levels was observed during hypoxia. Hemoglobin pretreatment also blocked the increase in intracellular calcium levels due to SNP (10 nmol/L) or hypoxia. Thus, increased availability of NO during SNP treatment or H-R, may have led to an ADP-ribosylation-mediated increase in intracellular calcium, thereby increasing the free radical generation from the rat PMNLs

Dyes derived from chrysoquinone

This article does not have an abstract

Minocycline, levodopa and MnTMPyP induced changes in the mitochondrial proteome profile of MPTP and maneb and paraquat mice models of Parkinson's disease

AbstractMitochondrial dysfunction is the foremost perpetrator of the nigrostriatal dopaminergic neurodegeneration leading to Parkinson's disease (PD). However, the roles played by majority of the mitochondrial proteins in PD pathogenesis have not yet been deciphered. The present study investigated the effects of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) and combined maneb and paraquat on the mitochondrial proteome of the nigrostriatal tissues in the presence or absence of minocycline, levodopa and manganese (III) tetrakis (1-methyl-4-pyridyl) porphyrin (MnTMPyP). The differentially expressed proteins were identified and proteome profiles were correlated with the pathological and biochemical anomalies induced by MPTP and maneb and paraquat. MPTP altered the expression of twelve while combined maneb and paraquat altered the expression of fourteen proteins. Minocycline, levodopa and MnTMPyP, respectively, restored the expression of three, seven and eight proteins in MPTP and seven, eight and eight proteins in maneb- and paraquat-treated groups. Although levodopa and MnTMPyP rescued from MPTP- and maneb- and paraquat-mediated increase in the microglial activation and decrease in manganese-superoxide dismutase expression and complex I activity, dopamine content and number of dopaminergic neurons, minocycline defended mainly against maneb- and paraquat-mediated alterations. The results demonstrate that MPTP and combined maneb and paraquat induce mitochondrial dysfunction and microglial activation and alter the expression of a bunch of mitochondrial proteins leading to the nigrostriatal dopaminergic neurodegeneration and minocycline, levodopa or MnTMPyP variably offset scores of such changes

Psychological impact among cancer patients undergoing chemotherapy in Bundelkhand region, Central India

Background: A cancer diagnosis can have a significant impact on mental health and wellbeing. Cancer is the second most common cause of death after heart diseases and it accounted for 9.6 million deaths worldwide in 2018. Various individual psychosocial and contextual factors potentially contribute to the development of anxiety and depression among people with cancer. In comparison with general people, the prevalence of anxiety and depression is frequently found to be higher among cancer patient, but estimates vary due to various factors, such as the type of cancer, treatment setting, and prognosis of disease. The present study was conducted to find out the estimate of depression in cancer patients undergoing chemotherapy and determine the various factors associated with depression.Methods: A cross-sectional study was conducted amongst cancer patients undergoing chemotherapy at Department of Oncology, Government Bundelkhand Medical College and Hospital, Sagar from January to April 2019. 150 participants were interviewed using predesigned questionnaire based on the Beck’s depression inventory.Results: Out of 150 cancer patients, 83 (55.3%) were found to be depressed. Depression was comparatively higher in patients’ ≥50 years; in males. Among the study patients, 83 (55.33%) had depression of which 21 (25.3%) had borderline clinical depression, 54 (65.06%) had moderate depression and 08 (9.6%) had severe depression.Conclusions: The study revealed depression in majority of patients receiving chemotherapy. Treatment of cancer patients need to be complemented by psychological support. Research is urgently needed into the possible impacts of long term effects of cancer treatment on mental health

Monocrotophos Induced Apoptosis in PC12 Cells: Role of Xenobiotic Metabolizing Cytochrome P450s

Monocrotophos (MCP) is a widely used organophosphate (OP) pesticide. We studied apoptotic changes and their correlation with expression of selected cytochrome P450s (CYPs) in PC12 cells exposed to MCP. A significant induction in reactive oxygen species (ROS) and decrease in glutathione (GSH) levels were observed in cells exposed to MCP. Following the exposure of PC12 cells to MCP (10−5 M), the levels of protein and mRNA expressions of caspase-3/9, Bax, Bcl2, P53, P21, GSTP1-1 were significantly upregulated, whereas the levels of Bclw, Mcl1 were downregulated. A significant induction in the expression of CYP1A1/1A2, 2B1/2B2, 2E1 was also observed in PC12 cells exposed to MCP (10−5 M), whereas induction of CYPs was insignificant in cells exposed to 10−6 M concentration of MCP. We believe that this is the first report showing altered expressions of selected CYPs in MCP-induced apoptosis in PC12 cells. These apoptotic changes were mitochondria mediated and regulated by caspase cascade. Our data confirm the involvement of specific CYPs in MCP-induced apoptosis in PC12 cells and also identifies possible cellular and molecular mechanisms of organophosphate pesticide-induced apoptosis in neuronal cells